Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction

Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. In both cell culture and the brains of immunocompromised mice, CD133-expressing glioma cells survive ionizing radiation in increased proportions

756 - 760 CrossRef View Record in Scopus Google Scholar Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Shideng Bao, et al., Nature, 444:756 (2006) Speaker : non-stem glioma cells due to preferential activation of the DNA damage response pathway [7]. Other groups also reported that the cancer stem cells of breast cancers were rela-tively resistant to radiation, potentially due to lower levels of reactive oxygen species found in cancer stem cells [14]. The emerging role of cancer stem cells in tumor Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells (GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance. The high entropy of GSCs is driven by a permissive epigenetic landscape and a mutational landscape that revokes crucial cellular checkpoints. In response to DNA damage, normal cells activate the DNA damage response (DDR), utilizing a variety of DNA damage sensing and repair pathways (e.g., base excision repair, nucleotide excision repair, homologous recombination, nonhomologous end-joining, mismatch repair, direct reversal) to maintain genomic integrity, whereas the inability to repair DNA damage leads to apoptosis . 2017-10-09 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 2006;5:67. It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines. The population doubling time was … 2018-05-21 · Previous studies showed that, preferential activation of the DNA damage checkpoint and enhanced DNA repair capacity in gliomas lead to radioresistance [9, 14, 15].

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444:756–60. Google Scholar | Crossref |

autologous stem cell transplantation, representing one of activated, further promoting cell survival, proliferation,. and growth MCM family members), DNA damage response signaling mide-like drug lenalidomide is preferentially suppressing metastasis, chemotherapy and/or radiation resistance in. HuR overexpression promotes cytoplasmic localization of β-catenin from the coordinates subcellular HuR distribution and leads to a preferential binding to U-rich overexpression attenuates stemness and radioresistance of glioma stem cells a novel regulator of cell proliferation, apoptosis and DNA damage response, HuR represses Wnt/Î²-catenin-mediated transcriptional activity by promoting Î²-Catenin accumulates in the nucleus of cancer cells where it activates oncogenic Different modes of interaction by TIAR and HuR with target RNA and DNA. HuR distribution and leads to a preferential binding to U-rich bearing target mRNA.

Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-60. Liu G, Yuan X, Zeng Z, et al. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 2006;5:67.

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Autores: Shideng Bao, Qing Shi, Yueling Hao, Roger E. McLendon, Darell D. Bigner, Qiulian Wu, Anita B. Hjelmeland, Jeremy N. Rich, Mark W. Dewhirst Add your e-mail address to receive free newsletters from SCIRP. In response to radiation, cells activate the DNA damage response (DDR), which initiates a series of cascades involving cell cycle checkpoint activation, various forms of DNA repair and, if unsuccessful, inducing apoptosis.

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 2019-08-27 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature , 444 ( 2006 ) , pp. 756 - 760 CrossRef View Record in Scopus Google Scholar Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Shideng Bao, et al., Nature, 444:756 (2006) Speaker : non-stem glioma cells due to preferential activation of the DNA damage response pathway [7]. Other groups also reported that the cancer stem cells of breast cancers were rela-tively resistant to radiation, potentially due to lower levels of reactive oxygen species found in cancer stem cells [14].
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7 Jan 2014 Protocol for propagation of dissociated high grade glioma surgical specimens in medium to select for cells with cancer stem cell phenotype.

now show that GSCs have co-opted a neurodevelopmental program to activate Rac1 to promote defining features of GSCs. Our previous study showed that increased activation of the DNA damage response is implicated in radioresistance of the glioma stem cells . To determine the mechanisms through which Notch promotes radioresistance of glioma stem cells, we first assessed whether the Notch pathway affected activation of the checkpoint kinases after radiation. Wang et al.
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8 Apr 2013 ATR functions in response to endogenous DNA damage; however, Glioma stem cells promote radioresistance by preferential activation of

Developing new therapeutic drugs combined with conventional therapy is strongly needed for GBM patients.

Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF Local irradiation does not enhance the effect of immunostimulatory AdCD40L results in a subpopulation of radioresistant cells with enhanced DNA-repair glioblastoma2015Ingår i: OncoTarget, ISSN 1949-2553, E-ISSN 1949-2553, Vol.

igenicity of experimental glioma-derived cancer initiating cells by preventing mainly due to the redundancy of the pathways as well as co-activation of the tyrosine kinases.

The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells3,4,5,6, is enriched after radiation in gliomas. cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour Notch inhibition with GSIs did not alter the DNA damage response of glioma stem cells following radiation, but rather impaired radiation-induced Akt activation and upregulated levels of the truncated apoptotic isoform of Mcl-1 (Mcl-1s).